Current ¥1,000 note (since 2004)
Hideyo Noguchi was a bacteriologist who worked extensively on diseases such as rabies, polio and syphilis. Noguchi wanted to become a doctor, but the severe burn on his left hand from a childhood injury meant hospitals were reluctant to hire him. Instead, he travelled to the United States, where he found work as a research assistant studying the properties of snake venom.
Despite being considered one of the most prominent figures in medical research during his active years, Noguchi's reputation came under scrutiny within a year of his death. Some of his findings were deemed inaccurate or couldn't be reproduced. Not only that, his methods of experimentation also came under fire as unethical, so perhaps it is just as well that the current ¥1,000 banknote will be replaced with one featuring a different bacteriologist.