Midwestern hospitality reaches new heights at this impressive urban hotel along the Mississippi River. St. Louis’ iconic Gateway Arch has never looked better than from the contemporary guest rooms and suites, outfitted with spacious, marble baths and floor-to-ceiling windows. Kick back on the eighth floor Sky Terrace, where you’ll find an expansive outdoor pool, chic cabanas and sweeping city views. The 12,000-square-foot spa offers relaxing massages, facials and other treatments, while Cielo bar and restaurant provides cooking classes allowing visitors to learn about the art of authentic Italian food. The concierge can help to arrange off-site activities from tickets to a Cardinals game to an outing at the Lumière Place Casino. From $250 per night
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