The snow is melting on the peaks of Great Smoky Mountains National Park, making it prime for hiking the Appalachian Trail and exploring surrounding towns. Asheville is as hip as it gets, with a Bohemian vibe and stellar culinary finds like the Indian street food haven Chai Pani and, for farm-fresh Southern food, Rhubarb.
Opt to stay at a hotel that is as hip as the town itself, The Radical, which has rad graffiti art in its rooms, a stellar wood-fire restaurant on-site (order the shellfish beignets) and river vistas. The Foundry is another great stay, with the most modern of industrial vibes, exposed brick walls and a Workshop Lounge with the friendliest of bartenders.
Travel time: 2 hours nonstop from FLL to Asheville